Molecular Hydrogen: managing side-effects of radiation for cancer therapy

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Cancer is often treated with radiation, yet the side-effects from radiation can add to the difficulty of managing and treating cancer.

Medical studies and scientific research have indicated that consumption of molecular hydrogen and specifically HydrogenWater can provide a better quality-of-life for people who are being treated with radiation, without diminishing the effectiveness of radiation against cancerous cells. This medical research is exciting because there are currently few methods available to address the side-effects of radiation, and many of these methods are not completely safe nor very effective.

Molecular hydrogen is also commonly known as hydrogen gas. One common method for consuming molecular hydrogen is the infusion of hydrogen gas in a beverage known as HydrogenWater. The FDA has recently issued a notice that molecular hydrogen is generally regarded as safe to be formulated in beverages.

This article provides an informative summary of published research that was conducted by independent research laboratories. Click the provided links to access and read the medical studies and scientific research.

croppedRadiation is a common method to treat cancer and address its symptoms. Unfortunately, radiation therapy is toxic to cancerous cells with little discrimination to the body’s healthy cells. Exposure to radiation can produce side-effects that are difficult to manage. These side-effects may be predictable yet individuals are often affected differently and even react differently to a new dose as compared to a previous dose. Listed below are a summary of the common side-effects of radiation exposure and potential benefits of molecular hydrogen: 

Quality-of-Life

Although overall survival of patients with malignant tumors should be the primary concern of a medical physician, it is also imperative to relieve the patient’s symptoms and improve their quality-of-life. A 2012 clinical study, published in part by the University of Pittsburgh (Pittsburgh, USA), provided the first evidence that HydrogenWater protects humans from the side-effects of radiation exposure. This clinical trial demonstrated that HydrogenWater improved the quality-of-life of patients who received radiation to treat their cancer diagnosis. HydrogenWater led to a significantly better appetite and fewer tasting disorders. These benefits were provided with no side-effects from HydrogenWater, which did not interfere with the effectiveness of radiation on tumors.

Cancer Reduction

Science is a well-renowned journal that announced the discovery that consumption of molecular hydrogen led to the regression of cancer that was caused by radiation. Baylor University (Waco, TX) conducted the study. In this scientific article, American researcher Dr. Malcom Dole was the first individual to clearly demonstrate that health benefits are provided with consumption of molecular hydrogen. After providing molecular hydrogen to mice that had skin cancer, Dr. Dole demonstrated that molecular hydrogen led to the regression of tumors.

Survival

HydrogenWater was shown to protect against death that is caused by radiation. In a study with mice that received molecular hydrogen, approximately 80% of these mice survived a lethal dose of radiation, whereas 90% of mice that did not receive molecular hydrogen died around two weeks.

Heart

Radiation can cause cardiac disease and chronically impair functions of the heart. In 2010, a research study indicated HydrogenWater prevented scarring (fibrosis) of hearts in mice that received radiation. Fibrosis is formed in many tissues (etc., skin, lung and liver) after radiation exposure and can cause these tissues to be less functional.

Cancer Prevention

While radiation can be used as a treatment for some cancers, radiation is a well known cause of other cancers and can promote the progression of cancer to a more aggressive disease. A key research paper has provided evidence that molecular hydrogen lowered the rate of cancer (thymic lymphomas) and increased the latency of these cancers that occur from radiation exposure.

Immunity (Spleen, Thymus and Gut)

One of the serious issues regarding radiation therapy is that these treatments can lead to a reduction in cells and decrease the functions of organs which are important for our immunity. A common cause of death from radiation is infection within the blood stream. As one of the most important immune organs, impairment of the spleen can lead to increased risk of infection, impaired wound healing and persistent inflammation. In 2014, scientific researchers studying a mouse-model for radiation exposure published that molecular hydrogen protected the size and function of the spleen and, while reducing inflammatory agents, prevented the massive killing of white blood cells such as lymphocytes and even restored the proliferation of blood cells. It is important to note that the thymus and gut are additional sources of immunity for the body. Scientific research has also indicated that molecular water protected the viability of the thymus and prevented a decrease in white blood cells and platelets, in addition to the evidence that molecular hydrogen protected intestinal tissue, in mice that received radiation.

Lung

The lung is an organ that is highly susceptible to radiation. Radiation can damage the lung directly after exposure and lead to a loss of pulmonary function from fibrosis that develops months or even years after radiation exposure. A published study has demonstrated that molecular hydrogen protected the lungs in mice that received radiation, including the ability of hydrogen gas to immediately prevent cell death and thereafter reduce the risk of developing fibrosis.

Fertility

Particularly in men, radiation can cause temporary or permanent infertility. The testis is appreciably sensitive to radiation because of the presence of rapidly, proliferating cells. It has been shown that molecular hydrogen can protect the size of the testis and sperm viability, quantity and motility while restoring testosterone levels.

Skin

Injuries of the skin, such as erythema, swelling, blisters and ulceration, followed by development of chronic inflammation, necrosis, fibrosis and lymphedema are common-side-effects of radiation exposure. Radiation-induced ulcers are often chronic and poor healing with a high relapse rate, and are commonly intractable. Studies have shown that molecular hydrogen accelerated wound healing and reduced inflammation of skin that was exposed to radiation.

Brain

Radiation can cause changes in the brain, especially when healthy brain cells are damaged and must be removed by the body’s repair systems. Dead or injured brain cells take up space and induce swelling, which can cause poor appetite, sleepiness, lack of energy, problems thinking clearly, difficulty managing tasks that were once easy, poor memory, confusion, personality changes, headaches and a worsening of old symptoms. These side effects may be immediate or delayed after radiation exposure. Scientific evidence indicates that molecular hydrogen protected against oxidation and cell death of nerve cells in brains of mice that were exposed to radiation.

Oxidation

Radiation produces toxic oxidants that indirectly cause widespread damage throughout the body. Japanese researchers demonstrated that an administration of molecular hydrogen neutralized oxidants and specifically the oxidant known as hydroxyl radical, which is key toxic factor generated with radiation exposure.

Conclusion

Molecular hydrogen and HydrogenWater have been shown to provide a better a quality-of-life for people who are being treated with radiation, without diminishing the effectiveness of radiation against cancerous cells.

Over 500 publications have discussed the health benefits of molecular hydrogen. The scientific community has known for decades that molecular hydrogen is a protective agent against cancer itself and the toxicities of cancer therapies such as radiation. Molecular hydrogen is natural, safer and an even more effective protective agent as compared to traditional treatments for radiation exposure. Medical studies and scientific research have indicated that molecular hydrogen protected against and reversed the side-effects of a single dose or multiple doses of radiation. Moreover, molecular hydrogen has been shown to reduce radiation injury to a variety of biological tissues and organs including the gut, bone marrow, testis, skin, lung, cardiovascular system, heart and brain.

There are traditional treatments for the side-effects of radiation exposure. However, these treatments often have significant shortcomings including relatively high toxicities and unfavorable routes of administration, which negatively affect their application and efficacy. Some of the side-effects include hypotension, nausea, vomiting and allergy even at low doses. Whereas, molecular hydrogen is a natural nutrient that is continuously produced by prokaryotic cells within the body and normally circulates in the blood. These characteristics make molecular hydrogen an ideal protectant against radiation injury and subsequent failure of cells, tissues and organs.

The health benefits of molecular hydrogen are not limited to individuals receiving radiation as cancer therapy. Other examples of persons who have suffered from radiation exposure are survivors of the Hiroshima and Nagasaki atomic bombs, and firefighters that first responded after the Chernobyl Nuclear Power Plant in 1986, as well as nuclear industry workers. As societies increase their utilization of radiation in energy production, and medical and industrial applications, there is an every increasing likelihood of radiation exposure to occupational workers, patients and the public. With the increasing prevalence of cancer, and the global issues caused by terrorist threats, nuclear war, dirty bombs or nuclear accidents, molecular hydrogen may give us more hope for greater survival and fewer human causalities.

Please continue to learn more by reading the provided citations, and share the information you learn to raise awareness for those who could benefit from the health benefits of molecular hydrogen. If you have any comments or questions, leave us feedback below and our medical scientists will provide answers from the published research.

Questions or Comments?

Question: If HydrogenWater increases the viability of normal cells, does HydrogenWater reduce the effectiveness of radiation on killing cancerous cells?  Fact: Studies indicate that HydrogenWater is not associated with any side-effects nor does molecular hydrogen decrease the medical benefits of radiation on cancers. Therefore, molecular hydrogen can address side-effects of radiation without reducing the anti-tumor effects.

Question: Is molecular hydrogen natural for the body?  Fact: The body naturally produces molecular hydrogen from prokaryotic cells that symbiotically reside in humans. Our blood circulates this molecular hydrogen and transports the hydrogen gas into tissues and organs, and ultimately into every cell.

htwo88CITATIONS:

Chuai, Y., Gao, F., Li, B., Zhao, L., Qian, L., Cao, F., … Cai, J. (2012). Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing hydroxyl radicals. The Biochemical Journal, 442(1), 49–56. http://doi.org/10.1042/BJ20111786

Chuai, Y., Qian, L., Sun, X., & Cai, J. (2012). Molecular hydrogen and radiation protection. Free Radical Research, 46(9), 1061–7. http://doi.org/10.3109/10715762.2012.689429

Chuai, Y., Shen, J., Qian, L., Wang, Y., Huang, Y., Gao, F., … Cai, J. (2012). Hydrogen-rich saline protects spermatogenesis and hematopoiesis in irradiated BALB/c mice. Medical Science Monitor?: International Medical Journal of Experimental and Clinical Research, 18(3), BR89–94. Retrieved from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3560739&tool=pmcentrez&rendertype=abstract

Chuai, Y., Zhao, L., Ni, J., Sun, D., Cui, J., Li, B., … Cai, J. (2011). A possible prevention strategy of radiation pneumonitis: combine radiotherapy with aerosol inhalation of hydrogen-rich solution. Medical Science Monitor?: International Medical Journal of Experimental and Clinical Research, 17(4), HY1–4. Retrieved from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3539519&tool=pmcentrez&rendertype=abstract

Dole, M., Wilson, F. R., & Fife, W. P. (1975). Hyperbaric hydrogen therapy: a possible treatment for cancer. Science (New York, N.Y.), 190(4210), 152–4. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/1166304

Hongmei, H., Shun, Y., Liesong, C., Haijun, L., Aidong, W., & Liyuan, Z. (2012). Hydrogen-rich saline alleviation on the oxidative stress and early-phase radiation-induced brain injury in rats. Retrieved from http://inis.iaea.org/Search/search.aspx?orig_q=RN:46111388

Jiang, Z., Xu, B., Yang, M., Li, Z., Zhang, Y., & Jiang, D. (2013). Protection by hydrogen against gamma ray-induced testicular damage in rats. Basic & Clinical Pharmacology & Toxicology, 112(3), 186–91. http://doi.org/10.1111/bcpt.12016

Kang, K.-M., Kang, Y.-N., Choi, I.-B., Gu, Y., Kawamura, T., Toyoda, Y., & Nakao, A. (2011). Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. Medical Gas Research, 1(1), 11. http://doi.org/10.1186/2045-9912-1-11

Liu, C., Cui, J., Sun, Q., & Cai, J. (2010). Hydrogen therapy may be an effective and specific novel treatment for acute radiation syndrome. Medical Hypotheses, 74(1), 145–6. http://doi.org/10.1016/j.mehy.2009.07.017

Mei, K., Zhao, S., Qian, L., Li, B., Ni, J., & Cai, J. (2014). Hydrogen protects rats from dermatitis caused by local radiation. The Journal of Dermatological Treatment, 25(2), 182–8. http://doi.org/10.3109/09546634.2012.762639

Ohsawa, I., Ishikawa, M., Takahashi, K., Watanabe, M., Nishimaki, K., Yamagata, K., … Ohta, S. (2007). Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nature Medicine, 13(6), 688–94. http://doi.org/10.1038/nm1577

Qian, L., Cao, F., Cui, J., Wang, Y., Huang, Y., Chuai, Y., … Cai, J. (2010). The potential cardioprotective effects of hydrogen in irradiated mice. Journal of Radiation Research, 51(6), 741–7. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21116102

Qian, L., Li, B., Cai, J., & Gao, F. (2010). The hypothesis of an effective safe and novel radioprotective agent: hydrogen-rich solution. The West Indian Medical Journal, 59(2), 122–4. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/21275114

Qian, L., Li, B., Cao, F., Huang, Y., Liu, S., Cai, J., & Gao, F. (2010). Hydrogen-rich PBS protects cultured human cells from ionizing radiation/induced cellular damage. Retrieved from http://inis.iaea.org/Search/search.aspx?orig_q=RN:41121438

Qian, L., Shen, J., Chuai, Y., & Cai, J. (2013). Hydrogen as a new class of radioprotective agent. International Journal of Biological Sciences, 9(9), 887–94. http://doi.org/10.7150/ijbs.7220

Schoenfeld, M. P., Ansari, R. R., Zakrajsek, J. F., Billiar, T. R., Toyoda, Y., Wink, D. A., & Nakao, A. (2011). Hydrogen therapy may reduce the risks related to radiation-induced oxidative stress in space flight. Medical Hypotheses, 76(1), 117–8. http://doi.org/10.1016/j.mehy.2010.08.046

Terasaki, Y., Ohsawa, I., Terasaki, M., Takahashi, M., Kunugi, S., Dedong, K., … Fukuda, Y. (2011). Hydrogen therapy attenuates irradiation-induced lung damage by reducing oxidative stress. American Journal of Physiology. Lung Cellular and Molecular Physiology, 301(4), L415–26. http://doi.org/10.1152/ajplung.00008.2011

Watanabe, S., Fujita, M., Ishihara, M., Tachibana, S., Yamamoto, Y., Kaji, T., … Kanatani, Y. (2014). Protective effect of inhalation of hydrogen gas on radiation-induced dermatitis and skin injury in rats. Journal of Radiation Research, 55(6), 1107–13. http://doi.org/10.1093/jrr/rru067

Yang, Y., Li, B., Liu, C., Chuai, Y., Lei, J., Gao, F., … Cai, J. (2012). Hydrogen-rich saline protects immunocytes from radiation-induced apoptosis. Medical Science Monitor?: International Medical Journal of Experimental and Clinical Research, 18(4), BR144–8. Retrieved from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3560832&tool=pmcentrez&rendertype=abstract

Zhao, L., Zhou, C., Zhang, J., Gao, F., Li, B., Chuai, Y., … Cai, J. (2011). Hydrogen protects mice from radiation induced thymic lymphoma in BALB/c mice. International Journal of Biological Sciences, 7(3), 297–300. Retrieved from http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3065742&tool=pmcentrez&rendertype=abstract

Zhao, S., Yang, Y., Liu, W., Xuan, Z., Wu, S., Yu, S., … Zhao, Y. (2014). Protective effect of hydrogen-rich saline against radiation-induced immune dysfunction. Journal of Cellular and Molecular Medicine, 18(5), 938–46. http://doi.org/10.1111/jcmm.12245

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